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Ahmad, Shrivastava, Ayaz, Singh, and Khanna: Tuberculous pyomyositis of upper and lower limb muscles- A prospective study


Introduction

Extra-pulmonary tuberculosis is considered as a new disease due to its resurgence and increasing incidence in the twenty-first century, particularly in immuno-compromised patients.1 About one-fifth of new diagnosed cases of tuberculosis have extrapulmonary lesion, of which about one-tenth involve the musculoskeletal system, arthritis, osteomyelitis and tubercular spondylitis. Tuberculous pyomyositis has been rarely described and its manifestations may mimic malignant tumour or other inflammatory disease as it presents as vague swelling.2 There are various routes of involvement of skeletal muscles as contiguous spread from underlying bony infection (osteomyelitis), neighbouring joint or tendon sheaths, or from cold abscess, by direct inoculation (penetrating injury) and by haematogenous dissemination. Still the involvement of soft tissue by Mycobacterium tuberculae without underlying bony pathology is very rare and the pathogenesis is not well understood. 3

Incidence of musculoskeletal tuberculosis occurs in only 3% of patients of all tubercular infections. Primary tuberculous pyomyositis is a rare infection constituting less than 1% of musculoskeletal tuberculosis. This can mimic inflammatory myositis or rarely mallignancy and can create diagnostic dilemma for orthopaedic surgeon. Mycobacterium tuberculae infection should always be considered as a rare but possible aetiology of myositis. Tuberculous pyomyositis in an immuno-competent patient without underlying bony involvement is an unusual presentation and its pathogenesis is still unclear.2

The route of infection was assumed to be one of three causes- ‘direct inoculation' if there had been a history of penetrating injury or surgery while the patient did not have pulmonary or other extra pulmonary tuberculosis, ‘contiguous spread’ if radiographic studies, revealed lesions in adjacent bone or soft tissues and ‘hematogenous’ in all other cases.4

Patients and Methods

The study was conducted at Mahamaya Rajkiya Allopathic Medical College, Ambedkar Nagar, on patients came to orthopaedic OPD during period between March-2012 to March-2019. It is a prospective study done on the OPD patients who came with complaints of pain, swelling with or without history of fever or trauma of both lower and upper limbs. Primarily they were diagnosed as soft tissue swelling, cold abscess or malignancy; on further evaluation, diagnosis was confirmed as Tubercular Pyomyositis.

Inclusion criteria

On the basis of observations we concluded the inclusion criteria which include both clinical and radiological parameters. Our inclusion criteria depend upon the following points-

  1. Patients presented with pain and swelling of long duration of more than two months

  2. Single swelling in the upper/lower limb

  3. No raised local temperature on palpation of swelling

  4. No redness or erythema of overlying skin

  5. No discharging sinus

  6. No bony involvement on X-ray

We framed the above inclusion criteria to rule out the common differential diagnosis like bacterial soft tissue infections and pyogenic abscess which presented with shorter duration of swelling with pain, temperature, fever and local soft tissue/bony tenderness. X-ray was done to exclude the common diagnosis like osteomyelitis and malignancy.

On the basis of above inclusion criteria we selected 28 patients and on further evaluations 16 patients diagnosed as tuberculous pyomyositis. During the study 2 patients had not visited for regular follow up.

There were 14 cases which included in this study. Among 14 cases there were 7 (50%) male and 7 (50%) female cases. The age of patients varied from 9 years to 68 years and the duration of illness at presentation in OPD from 2 months to 12 months. Out of 14 patients, 7 (50%) had problem in upper limb and 7(50%) in their lower limb.

Method of Evaluation and Management

Patients evaluated clinically followed by standard protocol as per suspicious swelling. All patients first evaluated clinically which includes history of contact of tuberculosis, duration of swelling, trauma and associated co-morbidities like diabetes mellitus, long standing steroid or immune-suppressant therapy, HIV infection. After that systemic and local examination was done on all the patients. The X-ray of the involved part was taken to look any pathology of the bone. Hematological parameters like haemoglobin, total leucocyte counts, differential leucocyte counts, blood sugar, ESR and CRP were done.

Ultrasonography (USG) was done to find out the nature of the swelling as solid or cystic, and to differentiate between superficial swellings of subcutaneous tissue from the deep swelling of muscle. Magnetic resonance imaging (MRI) was done to reveal the extension of the swelling of the involved muscle. For small swellings Fine Needle Aspiration Cytology (FNAC) was done. In large swelling aspiration was done with large bore needle and aspirate sent for gram staining, AFB staining, culture and sensitivity.

In very large swelling surgical drainage and debridement was done and tissue sent for histopathological examination. In some swelling biopsy was done to confirm the diagnosis. In all cases we had started symptomatic treatment from the first day visit in the form of NSAIDS, and once the diagnosis had been confirmed we started anti tubercular treatment (ATT) as per guideline of management of extra pulmonary tuberculosis for at least one year.

Patients having other co morbidities like diabetes mellitus as 2 of our patients, had continued the anti-diabetic drugs along with treatment of tubercular pyomyositis. All the managed patients doing well and they have taken their full course of ATT as per protocol till the last review.

Table 1

Detail of patients

S.No Age(y)/sex Location Duration on first presentation MRI Other comorbities Route Initial diagnosis Management Bony involvement
1 9/m Right proximal medial thigh 4 months 6x6x2cm, Adductor compartment None Hematogenous Infection Conservative None
2 22/f Right distal arm posterioly 3 months 150x31x16mm, distal half of Triceps None Hematogenous Cold abscess Surgical Superficial erosion of olecranon process
3 24/f Lateral aspect of right forearm 4 months 5x3x2cm,belly of Brachioradialis None Hematogenous Infection Surgical None
4 55/m Right lower leg 2 months 6x6x4 cm of lower calf muscle Diabeties mellitus Direct (penetrating injury) Infection Surgical None
5 24/f Lateral compartment of right thigh 5 months 185x31x69mm Vastus lateralis & intermedius None Hematogenous Cold Abscess Surgical None
6 60/m Right proximal thigh 7 months 15x12x8 cm, Quadriceps Femoris Pulmonary TB Hematogenous Cold Abscess Surgical None
7 23/f Anterior aspect of left forearm 12 months 8x4x2mm, Flexor digitorum superficialis None Hematogenous Infection Conservative None
8 68/f Anterior & lateral aspect of left thigh 7 months 4x5x3 cm, Vastus lateralis & Vastus intermedius Diabetes mellitus Hematogenous Malignancy Conservative None
9 38/m Anterior aspect of right forearm 9 months 55 x 28 x 26 mm, in the flexor compartment muscle None Direct (penetrating injury) Infection Surgical None
10 30/m Left forefoot 4 months 22x16x8mm, flexor compartment muscles of foot None Direct (penetrating injury) Infection Surgical None
11 26/f Lateral aspect of right forearm 6 months 5x3x2cm, belly of Brachioradialis None Hematogenous Infection Surgical None
12 12/m Anterior aspect of left thigh 4 months 3x2x1 cm, Quadriceps femoris None Hematogenous Mallignancy Conservative None
13 55/m Medial aspect of left thigh 11 months 6x3x3cm, Adductor muscle None Hmatogenous Soft tissue tumor Conservative None
14 36/f Anterior aspect of proximal forearm right 8 months 3x4x2cm, Flexor compartment None Hematogenous Swelling Conservative None

Result

Management of tuberculosis is not a big issue in present scenario as we have different kind of anti-tubercular drugs and their protocol even for the resistant cases. The only problem is its proper diagnosis and mode of presentation. Tuberculous pyomyositis is a rare condition and mostly common in immuno-compromised patients but unfortunately it is not true with our study.

Depends upon their clinical presentation initially 28 cases were suspected among which 16 cases (57.10%) found positive for tuberculous pyomyositis. Two patients were lost during follow up, so finally there were 14 cases (50%) included in this study. Among 14 cases, 7 cases (50%) were female and 7 cases (50%) male. The age of patients varied from 9 year to 68 year and the duration of illness at presentation from 2 months to 12 months. The routes of infection were hematogenous in 11 cases (78.57%) and penetrating injury in 3 cases (21.42%). All cases were managed with ATT schedule as per guideline and surgery also needed in 8 cases (72.72%).

All the patients had received ATT for at least one year, and regular follow up was done up to six months after the completion of treatment. All the patients had developed some form of muscle contracture owing to disease of the muscle, for which we advised for physiotherapy.

Figure 1

a,b:- MRI showing pyomyositis of Adductor muscles- loculated collection displaying heterogamous hyperintense signal on T2W and STIR images and hypointense signal on T1W is noted in the adductor compartment of right upper thigh with moderate surrounding edema measuring approximately 6x6x2 cm.

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Figure 2

a,b:- MRI is showing pyomyositis of Quadriceps Femoris muscle - ill defined T2W hyper-intensity seen in thigh involving vastus lateralis and intermedius muscle. It measures approximately 185x31x69mm. It is displaying low signal intensity on T1W image and hyperintense on T2/TRIM images. A tiny similar area is seen in adductor magnus muscle.

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Figure 3

a,b:- MRI is showing involvement of Triceps muscles – an irregular large collection in the triceps muscle extending from mid arm to the olecranon process measuring approximately 150x31x16mm with subcutaneous extension. It is hypointense on T1W image and hyperintense on T2/TIRM images. There is superficial erosion of the olecranon process identified.

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Discussion

Pyomyositis is the bacterial infection of skeletal muscle with abscess formation, but when the causative micro-organism is Mycobacterium tuberculae, known as Tuberculous Pyomyositis. The real pathogenesis is still not clear but there are factors like penetrating injury, nutritional deficiencies, septic load, viral infections and parasitic infestations have been implicated as the predisposing factors.4 Infection with Mycobacterium tuberculae is a rare cause of pyomyositis, particularly in immuno-competent patients as per literature but in endemic regions like India the pyomyositis may occur in a normal person. The rarity is also proven by literature as study done by J. Y. Wang et al. on 1153 suspects published in 2003; only 21 patients (1.8%) with culture-proven tuberculosis had tuberculous pyomyositis.5

Though the muscle involvement is rare in Mycobacterium tuberculae infection and there is possible explanations for the rarity of muscle involvement in tuberculosis include the high lactic acid content of the muscle, absence of lymphatic tissue and reticulo-endothelial tissue, well differentiated state of muscular tissue, and its good vascular supply.6 The infection with Mycobacterium tuberculae bacilli involves a single large muscle, like quadriceps femoris, gastrocnemius, adductor longus/magnus, brachioradialis, flexor digitorum superficialis/profundus, biceps and triceps.

There are many explanations that the involvement of skeletal muscle is secondary to Mycobacterium tuberculae infection of underlying bones, synovial sheaths of nearby tubercular arthritis, by direct inoculation (penetrating injury) or hematogenous dissemination.7 Just reverse to this concept some authors have reported tuberculosis of muscles as the primary site for infection.8 In the absence of a direct spread from an adjacent primary focus, tuberculous pyomyositis may be found in penetrating injury, idiopathic in an immuno-competent host or there was no evidence of a tubercular focus elsewhere in the body as primary involvement.

Most common cause of tuberculous pyomyositis is typically caused by invasion from adjacent structures rather than by primary infection, hematogenous seeding or lymphatic spread9 but in our study hematogenous spread was the most common route of infection. The prevalence of tuberculous pyomyositis is more common in immuno-deficient patients and associated with the use of corticosteroids, the presence of HIV infection, the administration of cancer chemotherapy, and renal failure.10

There are many case reports in literature supporting this evidence like a case report presented by Siao-pin Simon et al. reported a 66 year old female patient on immuno-depressent therapy presents with tuberculous pyomyositis of her right thigh muscle;11 and by Pradeep Khandalvalli et al. presented a case report in 2019 of an immuno-compromised patients, a 35 year old female renal allograft recipient presented with multiple subcutaneous abscess involving left forearm, left thigh, suture site and left loin, which on later evaluation revealed to be due to Mycobacterium tuberculae.12

Tuberculous pyomyositis can develop in immuno-competent persons, with the common symptoms of Mycobacterium tuberculae infection such as evening rise of temperature, night sweats, malaise, loss of appetite, and weight loss.13

The diagnosis of tuberculous pyomyositis is still mostly based on clinical suspicion such as its insidious onset, slow progression, non-responsiveness to various antibiotics, and by its responsiveness to anti-tubercular chemotherapy retrospectively, as described in literature but many times only a vague swelling of long duration is the only presentation. The typical symptoms are more common in immuno-compromised patients as compared to immuno-competent patients as per literature. There are differential diagnosis which includes bacterial, fungal, or tuberculous abscesses, hematoma and neoplasm.14

A positive tuberculin test only helps as a guide to the suspicion of Mycobacterium tuberculae infection but may not be positive always. Demonstration of acid-fast bacilli (AFB) on Ziehl– Neelsen stain from the aspirate from swelling may further confirm the etiology. However this may not be true in some cases if the bacterial load in the abscess is low. In such cases, the aspirate may be negative for AFB stain despite the abscess being of Mycobacterium tuberculae infection. A pathological report of granulomatous inflammation is beneficial in the early diagnosis of tuberculous pyomyositis, even if the AFB stain is negative. That is why we had advised for all patients FNAC and aspiration, and in some cases histopathological evaluation was done in which AFB staining failed to demonstrate acid fast bacilli.15

On hematological evaluation laboratory parameters in patients with tuberculous pyomyositis may include low haemoglobin, leukocytosis, an elevated erythrocyte sedimentation rate (ESR), and elevated creatine phosphokinase (CPK) levels, though none of these is specific to this particular diagnosis and none are seen in each case.16

Imaging modalities such as ultrasonography (USG), computed tomography scan (CT scan), and MRI is important in diagnosing pyomyositis. The location, extent, and consistency of a swelling can be determined by these imaging studies, which aid the process of establishing a differential diagnosis of tuberculous pyomyositis. We did USG and MRI for all of our cases to know the extent of involvement of infection.17

MRI is the best modality for evaluating soft-tissue masses, including inflammatory infectious processes. Still, when T1- and T2-weighted images are used, it is sometimes difficult or even impossible to differentiate neoplastic (benign or malignant) from non-neoplastic swellings, including inflammatory swellings. MRI helps well to establish the extent of involvement of bone. There was no bony involvement except superficial bony erosion in one of our case on MRI. The small areas of relatively low signal intensity within the abscess on the T2-weighted images generally represent necrotic material and proteinaceous debris. 18

Pyomyositis, which is due to pyogenic bacterial organisms, has three clinical stages-19

  1. Invasive stage- clinical symptoms are mild with pain, fever, and anorexia, the disease being in a subacute form.

  2. Suppurative stage- high grade fever, chills, myalgia, septic syndrome and fluctuation in the muscle due to the presence of pus.

  3. Stage of systemic manifestations- sepsis and fever with possibility of complications like metastatic abscesses, arthritis, septic shock and renal failure.

Treatment of pyomyositis is surgical drainage or USG/CT-guided drainage of the abscesses with administration of appropriate intravenous antibiotics. Pyomyositis of tubercular origin is comparatively rare and does not follow the classical three stages of pyogenic pyomyositis. The literatures have reported few cases of tuberculous pyomyositis treated with surgical drainage and debridement, with recurrence requiring further surgeries.18, 20

There is no specific guideline for the management of tuberculous pyomyositis, though the cornerstone happens to be early diagnosis and anti-tubercular chemotherapy.21

Effective drainage of the abscess must be ensured by aspiration or by surgical exploration. The surgical option may be reserved for the following conditions, such as – 22, 23

  1. A rapid enlarging painful swelling acting as space-occupying lesions and causing jeopardization of other functional structures in the vicinity.

  2. Recurrence after aspiration or debridement

  3. Immuno-compromised state, where the bacterial load is high

  4. Associated with bony erosion

  5. A Doubtful diagnosis.

  6. Non-responsiveness to anti-tubercular drugs despite culture being positive for Mycobacterium tuberculae

  7. Failed aspiration of the abscess and thereby lack of effective drainage

A high level of clinical suspicion supplemented with mycobacteriological testing and relevant imaging study is necessary to make an early diagnosis of tuberculous pyomyositis. In most cases, receiving timely diagnosis, effective drainage, and appropriate anti-tubercular chemotherapy, the prognosis for functional recovery is good.

There are few limitations of our study like there is no immuno-compromised patients in this study as the patients included in this study are selected randomly on the basis of our inclusion criteria. Tubercular pyomyositis is a rare disease so it needs a long duration for study for example as in literature a retrospective study was done by J. Y. Wang et al. on 1153 suspects published in 2003 the duration from January 1996 to March 2001, but only 21 (1.8%) patients had diagnosis of tuberculous pyomyositis,5 and in our study during the period of March 2012 to March 2019 total 28 patients initially selected on the basis of our inclusion criteria among which 14 (50%) patients found to be tuberculous pyomyositis. This is the limitation of our study and is due to the small number of patients; but on other side it also proves the efficacy of our inclusion criteria as there were 50% of suspects had tuberculous pyomyositis.

Conclusion

Isolated presentation of tuberculosis as pyomyositis is rare and not widely reported in the literature. Tuberculous pyomyositis should be considered in long standing vague swelling of the upper and lower limb without constitutional symptoms and signs of inflammations. Thus it is our recommendation is to establish the diagnosis of tubercular pyomyositis followed by anti tubercular treatment; and in selected cases surgical drainage and debridement along with ATT.

Consent

The written and informed consent was obtained from the every patient for the publication of this paper and any accompanying images.

Source of Funding

None.

Conflict of Interests

None.

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