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Umbilical cord derived mesenchymal stem cell therapy for osteonecrosis of femoral head


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Review Article

Author Details : Madu Sridhar*, Manish Khanna, Venus Khanna

Volume : 6, Issue : 2, Year : 2020

Article Page : 50-53

https://doi.org/10.18231/j.ijor.2020.012



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Abstract

Osteo Necrosis of the Femoral Head (ONFH) is a form of osteonecrosis that occurs owing to interruption of blood supply to the proximal femur followed by fragmentation, reossification, and remodelling of the femoral head. In United States, the incidence of avascular necrosis of the femoral head is projected to be around 30000, which contributes to 10% of the total hip replacement done every year. It was believed that necrosis of proximal femur occurs due to the inadequate supply of progenitor cells in the femoral head. So, treatment is aimed at introducing stem cells in necrosis area in order to avoid the risk of fracture and
collapse to restore the structural design of femoral head. The objective of this review is to highlight the potential of mesenchymal stem cell (MSC) therapy along with core decompression for the management of ONFH with a special reference to umbilical cord-derived stem cells.

Keywords: Umbilical cord, Mesenchymal stem cells, Osteonecrosis, Femoral head, Avascular necrosis.



How to cite : Sridhar M , Khanna M , Khanna V , Umbilical cord derived mesenchymal stem cell therapy for osteonecrosis of femoral head. IP Int J Orthop Rheumatol 2020;6(2):50-53


Copyright © 2020 by author(s) and IP Int J Orthop Rheumatol. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)